Throughout the course of human evolution, humans have been solving complex problems. In this paper, various system theories such as General Systems Theory, Chaos Theory, Complex-Adaptive Systems, and Integral Theory are described and discussed within the context of the human body. Different systems of varying context, such as: (1) when facilitating sustainable changes in organizations; (2) when promoting the unification of health care teams to enhance patient care; and (3) when explaining treatment principles in oncology, are also described and discussed in this paper, using systems theory as a framework. Systems theory has many applications, not only in leadership and organization, but also in oncology. Leaders need to be systems thinkers in order to facilitate sustainable change in their organizations.
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